Supporting Scientific Literature

Daily Health:

Rizzardini et al., 2012 Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12wand Lactobacillus paracasei ssp. paracasei, L. casei 431w in an influenzavaccination model: a randomised, double-blind, placebo-controlled study. British Journal of Nutrition, 107, 876–884

Costa et al., 2014 Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis: a double-blind, randomized, placebo-controlled trial. European Journal of Clinical Nutrition,68, 602–607

Hor et al., 2018 Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions. Journal of Functional Foods,44, 235–245

Jespersen et al., 2015 Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study.  American J Clinical Nutrition; 101:1188–96

He et al., 2020 Long-term administration of Lactobacillus caseiZhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults. Journal of Functional Foods, 64,103682

Chen et al., 2019 Differential effects of Lactobacillus casei strain Shirota on Patients With Constipation Regarding Stool Consistency in China. Journal of Neurogastroenterology. 25(1): 148-158

Mai et al., 2020 Efficacy of probiotics on digestive disorders andacute respiratory infections: a controlled clinical trial in young Vietnamesechildren. European Journal of Clinical Nutrition

Sakai et al., 2011 Fermented milk containing Lactobacillus casei strain Shirota reduces incidence of hard or lumpy stools in healthy population. International journal of food sciences and nutrition. 62(4): 423-430

Zhang et al., 2013 Lactobacillus paracasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in HealthyY oung Adults. Journal of Microbiology,e51, p777-782

Plaza Diaz et al., 2016 Pyrosequencing Analysis Reveals Changes in Intestinal Microbiota of Healthy Adults Who Received a Daily Dose of Immunomodulatory Probiotic Strains. Nutrients, e7, p3999-4015

Van den Nieuwboer et al., 2015 Improving the bowel habits of elderly residents in a nursing home using probiotic fermented milk. Beneficial Microbes. 6(4): 397-403

Koebneck et al., 2003 Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms inpatients with chronic constipation. Canadian Journal of Gastroenterology. 17(11): 655

Ou et al., 2019 Lactobacillus casei Strain Shirota Alleviates Constipation in Adults by Increasing the Pipecolinic Acid Level in the Gut. Frontiers in Microbiology. 10: 324

 

 

Digestive

Ou, 2019 Lactobacillus casei Strain Shirota Alleviates Constipation in Adults by Increasing the Pipecolinic Acid Level in the Gut. Frontiers in Microbiology. 10: 324.

Kato-Katoaka, 2016 Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress. Applied and Environmental Microbiology. 82:3649-3658

Wang, 2015 Intestinal Microbiota Profiles of Healthy Pre-School and School-Age Children and Effects of Probiotic Supplementation. Nutrition and Metabolism. 67: 257-266

Matsumoto, 2010 Effects of a probiotic fermented milk beverage containing Lactobacillus casei strain Shirota on defecation frequency, intestinal microbiota, and the intestinal environment of healthy individuals with soft stools. Journal of Bioscience and Bioengineering. 110(5):547-552

Koebneck, 2003 Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Canadian Journal of Gastroenterology. 17(11): 655

van den Nieuwboer, 2015 Improving the bowel habits of elderly residents in a nursing home using probiotic fermented milk. Beneficial Microbes. 6(4): 397-403.

Aoyagi, 2019 Independent and Interactive Effects of Habitually Ingesting Fermented Milk Products Containing Lactobacillus casei Strain Shirota and of Engaging in Moderate Habitual Daily Physical Activity on the Intestinal Health of Older People. Frontiers in Microbiology. 10: 1477

Chen et al., 2019 Differential effects of Lactobacillus casei strain Shirota on Patients With Constipation Regarding Stool Consistency in China. Journal of Neurogastroenterology. 25(1): 148-158

Mai et al., 2020 Efficacy of probiotics on digestive disorders and acute respiratory infections: a controlled clinical trial in young Vietnamese children. European Journal of Clinical Nutrition

Sakai et al., 2011 Fermented milk containing Lactobacillus casei strain Shirota reduces incidence of hard or lumpy stools in healthy population. International journal of food sciences and nutrition. 62(4): 423-430

Lewis 2020 Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study. Nutrients. 12: 1159; doi:10.3390/nu12041159

Valerio 2011 Role of the probiotic strain Lactobacillus paracaseiLMGP22043 carried by artichokes in influencing faecal bacteria and biochemical parameters in human subjects. Journal of Applied Microbiology. 111(1):155-64

Lombardo 2009 Clinical evaluation of Lactobacillus paracaseisubsp. paracasei F19 with gluco-oligosaccharides in the short-term treatment ofirritable bowel syndrome. Microbial Ecology in Health and Disease. 21: 28-32

Lahner 2012 High-fibre diet and Lactobacillus paracasei B21060in symptomatic uncomplicated diverticular disease. World Journal of Gastroenterology

 

Immune

Rask et al. 2012. Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli. British Society for Immunology, Clinical and experimental Immunology,e172, p321-332

Corsello et al. 2019. Preventive
Effect of Cow’s Milk Fermented with Lactobacillus paracasei CBA L74 on Common Infectious Diseases in Children: A Multi-centre Randomized Controlled Trial. Nutrients, 9(7), 669

Nocerino et al. 2015. Cow's milk and rice fermented with Lactobacillus paracasei CBA L74 prevent infectious diseases in children: A randomized controlled trial. Clinical Nutrition, e36, p118-125

Fangfang et al. 2017. Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial. Clinical Interventions in Aging, e12, p1223-1231

Shida et al. 2017. Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle‑aged office workers. European J. of Nutrition, e56, p45-53

Jesperson et al. 2015. Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study. American J. Clinical Nutrition, e101, p1188-1196

Plaza-Diazet al., 2016. Pyrosequencing Analysis Reveals Changes in Intestinal Microbiota of Healthy Adults Who Received a Daily Dose of Immunomodulatory Probiotic Strains. Nutrients, e7, p3999-4015.

Zhang et al., 2013. Lactobacillusparacasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in Healthy Young Adults. Journal of Microbiology, e51, p777-782

Costa et al., 2014. Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis: a double-blind, randomized, placebo-controlled trial (GA2LEN Study). European journal of clinical nutrition, e68, p602-607.

Ivory et al. 2008. Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis. Clinical and Experimental Allergy. 38(8): 1282-1289.

Dong et al. 2013. Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers. European Journal of Nutritition.